In Preparation

CE Carr, N Bryan, K Saboda, A Mojarro, J Hachey, SA Bhattaru, G Ruvkun, MT Zuber. Nucleic Acid Sequencing Under Mars-Like Conditions.


Submitted/In Review

A. Mojarro, J. Hachey, R. Bailey, M. Brown, R. Doebler, G. Ruvkun, M. T. Zuber, C. E. Carr. Nucleic Acid Extraction and Sequencing from Low-Biomass Synthetic Mars Analog Soils for In Situ Life Detection. Astrobiology (Submitted 7/2/18, AST-2018-1929). Preprint: bioRxiv 358218; https://doi.org/10.1101/358218

Carr CE, Saboda K, Ruvkun G, Zuber MT, Wassmann M, Rettberg P, Moeller R. Informational polymers as unambiguous biomarkers for aqueous-based life. European Astrobiology Network Association (EANA), Berlin, Germany, 24-28 September, 2018 (abstract, submitted 6/29/18)

SA Bhattaru, J Tani, CE Carr. Automation and Rapid Prototyping of a Nucleic Acid-Based Life Detection Instrument. Aerospace Conference, 2018 IEEE. March 3-10, Big Sky, MT, USA. Session 2.07 In Situ Instruments for Landed Surface Exploration, Orbiters and Flybys. Abstract (submitted 6/29/18)

K Saboda, R Moeller, CE Carr. Enabling Measurement of Darwinian Evolution in Space. Aerospace Conference, 2018 IEEE. March 3-10, Big Sky, MT, USA. Session 2.07 In Situ Instruments for Landed Surface Exploration, Orbiters and Flybys. Abstract (paper 2077; submitted 6/24/18)

Carr CE, Samuelson AV, Llop J, Ruvkun G. Two Paths to Longevity: Lower Noise, Slower Ageing. Scientific Reports


Published

Google Scholar | ResearchGate

Peer Reviewed Publications (40)

40. Carr CE, Bryan NC, Saboda K, Bhattaru SA, Ruvkun G, Zuber MT. Acceleration Profiles and Processing Methods for Parabolic Flight. npj Microgravity 4, Article number: 14 (2018) https://doi.org/10.1038/s41526-018-0050-3. Preprint: arXiv:1712.05737; code: https://github.com/CarrCE/zerog; data: https://osf.io/nk2w4/

39. A. Ponrefract, J. Hachey, M. T. Zuber, G. Ruvkun, C. E. Carr. Sequencing Nothing: Exploring Failure Modes of Nanopore Sensing and Implications for Life Detection. Life Sciences in Space Research 2018 In Press doi:10.1016/j.lssr.2018.05.004 OpenAccess

38. Mojarro A, Hachey J, Ruvkun G, Zuber MT, Carr CE. CarrierSeq: a sequence analysis workflow for low-input nanopore sequencing. BMC Bioinformatics, 2018, 19:108, doi: 10.1186/s12859-018-2124-3   Preprint available at: bioRxiv https://doi.org/10.1101/175281; code: https://github.com/amojarro/carrierseq; data: https://doi.org/10.6084/m9.figshare.5471824.v1

37. Pontefract A, Zhu TF, Walker VK, Rowedder H, Lui C, Zuber MT, Ruvkun G, Carr CE. Microbial Diversity in a Hypersaline Sulfate Lake: An Analog of Ancient Mars. Frontiers in Microbiology, 26 Sept 2017 doi: 10.3389/fmicb.2017.01819 PMID 29018418 OpenAccess

36. Webster CM, Pino EC, Carr CE, Wu L, Zhou B, Kacergis MC, Curran SP, Soukas AA. Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival. Cell Reports. 18 July 2017, 20(3):627–40 doi:10.1016/j.celrep.2017.06.068 OpenAccess

35. Mojarro A, Ruvkun G, Zuber MT, Carr CE. Nucleic acid extraction from synthetic Mars analog soils for in situ life detection. Astrobiology 2017 Jul 13. doi: 10.1089/ast.2016.1535 PMID 28704064 OpenAccess

34. Paull L, Tani J, Ahn H, Alonso-Mora J, Carlone L, Cap M, Chen YF, Choi C, Dusek J, Fang Y, Hoehener D, Liu SY, Novitzky M, Okuyama IF, Pazis J, Rosman G, Varricchio V, Wang HC, Yershov D, Zhao H, Benjamin M, Carr CE, Zuber M, Karaman S, Frazzoli E, Del Vecchio D, Rus D, How J, Leonard J, Censi A. Duckietown: An Open, Inexpensive and Flexible Platform for Autonomy Education and Research. 2017 IEEE International Conference on Robotics and Automation (ICRA), May 29 - June 3, 2017, Marina Bay Sands Convention Centre, Singapore. doi:10.1109/ICRA.2017.7989179

33. Carr CE, Mojarro A, Hachey J, Saboda K, Tani J, Bhattaru SA, Smith A, Pontefract A, Zuber MT, Finney M, Doebler R, Brown M, Talbot R, Nguyen V, Bailey R, Ferguson T, Church G, Ruvkun G. Towards In Situ Sequencing for Life Detection. Aerospace Conference, 2017 IEEE. March 4-11, Big Sky, MT, USA, pp. 1-18. Session 2.07 In Situ Instruments for Landed Surface Exploration, Orbiters and Flybys. Paper # 2353 doi:10.1109/AERO.2017.7943896, Author Manuscript.

32. Carr CE, Newman DJ. Exoskeleton Energetics: Implications for Planetary Extravehicular Activity. Aerospace Conference, 2017 IEEE. March 4-11, Big Sky, Montana. Session 8.06 Space Human Physiology and Countermeasures. Paper # 2354. doi: 10.1109/AERO.2017.7943712, Author Manuscript.

31. Bhattaru SA, Tani J, Carr CE. Cold Testing of Conductive Bridging Random Access Memory for Space Applications. Aerospace Conference, 2017 IEEE. March 4-11, Big Sky, Montana. Session 7.09 Electronics for Extreme Environments. Paper # 2250. doi: 10.1109/AERO.2017.7943828, Author Manuscript.

30. L Wu, M Li, N Oshiro-Rapley, B Zhou, CM Webster, F Mou, MC Kacergis, ME Talkowski, CE Carr, B Zheng, AA Soukas. An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer. Cell 167(7):1705-18, 15 Dec 2016; doi: 10.1016/j.cell.2016.11.055, PMC5390486 (2017/12/15).

29. Carr CE, Mojarro A, Tani J, Bhattaru SA, Zuber MT, Doebler R, Brown M, Herrington K, Talbot R, Fuller C, Finney M, Church G, Ruvkun G. Advancing the Search for Extra-Terrestrial Genomes. Aerospace Conference, 2016 IEEE, March 5-12, Big Sky, Montana. doi: 10.1109/AERO.2016.7500859  

28. Carr CE. Optimal Space Suit Mass for Mars Extravehicular Activity. Aerospace Conference, 2016 IEEE, March 5-12, Big Sky, Montana. doi: 10.1109/AERO.2016.7500869

27. Wang MC, Oakley HD, Carr CE, Sowa JN, and Ruvkun G. Gene pathways that delay Caenorhabditis elegans reproductive senescence. PLoS Genetics 10(12): e1004752 (2014) doi: 10.1371/journal.pgen.1004752 OpenAccess

26. Sasaki T, Lian S, Qi J, Bayliss PE, Carr CE, Johnson JL, Guha S, Kobler P, Catz SD, Gill M, Jia K, Klionsky DJ, Kishi S. Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency. PLoS Genetics 10(6): e1004409. doi:10.1371/journal.pgen.1004409 OpenAccess.

25. Soukas AA, Carr CE, Ruvkun G (2013). Genetic Regulation of Caenorhabditis elegans Lysosome Related Organelle Function. PLoS Genet 9(10): e1003908. doi: 10.1371/journal.pgen.1003908 OpenAccess.

24. Carr CE, Rowedder H, Lui C, Zlatkovsky I, Papalias CW, Bolander J, Myers J, Rothberg JM, Zuber MT, Ruvkun G (2013). Radiation resistance of sequencing chips for in-situ life detection. Astrobiology, 13(6). doi:10.1089/ast.2012.0923

23. Carr CE, Zuber MT, Ruvkun G. Life Detection with the Enceladus Orbiting Sequencer. Aerospace Conference, 2013 IEEE (2-9 March 2013). Paper # 2368. doi:10.1109/AERO.2013.6497129

22. Carr CE, Rowedder H, Vafadari C, Lui C, Cascio E, Zuber M, and Ruvkun G. Radiation resistance of biological reagents for in-situ life detection. Astrobiology Jan 2013, 13(1): 68-78. doi:10.1089/ast.2012.0869. PMID: 23330963

21. Pino L, Webster C, Carr CE, Soukas AA. Biochemical and high throughput microscopic assessment of fat mass in Caenorhabditis elegans. J Vis Exp 2013 Mar 30 (73) doi:10.3791/50180.

20. Shore DE, Carr CE, Ruvkun G (2012) Induction of Cytoprotective Pathways Is Central to the Extension of Lifespan Conferred by Multiple Longevity Pathways. PLoS Genet 8(7): e1002792. doi:10.1371/journal.pgen.1002792

19. Lui C, Carr CE, Rowedder H, Ruvkun G, Zuber M. SETG: An instrument for detection of life on Mars ancestrally related to life on Earth. Aerospace Conference, 2011 IEEE (11 April 2011). doi: 10.1109/AERO.2011.5747299.

18. Koshimizu E, Imamura S, Qi J, Toure J, Valdez DM Jr, Carr CE, Hanai J, and Kishi S. 2011 Embryonic Senescence and Laminopathies in a Progeroid Zebrafish Model. PLoS ONE 6(3): e17688. doi:10.1371/journal.pone.0017688. PMCID: PMC3068137

17. O’Rourke E, Soukas A, Carr CE, and Ruvkun G. C. elegans Major Fats are stored in vesicles distinct from lysosome-related organelles. Cell Metabolism 4 Nov 2009 10(5):430-435; doi:10.1016/j.cmet.2009.10.002.

16. Carr CE, McGee J (2009). The Apollo Number: How space suits affect the walk-run transition. PLoS ONE 4(8): e6614; doi: 10.1371/journal.pone.0006614.

15. Soukas AA, Kane EA, Carr CE, Melo JA, and Ruvkun G. Caenorhabditis elegans Rictor/TORC2 regulates fat metabolism and lifespan in a diet-dependent manner. Genes & Development (2009) 23:496-511; doi: 10.1101/gad.1775409.

14. Isenbarger TA*, Carr CE*, Johnson SS, Finney M, Church GM, Gilbert W, Zuber MT, Ruvkun G. The most conserved genome segments for life detection on Earth and other planets. Orig Life Evol Biosph (2008), 38:517–33, doi: 10.1007/s11084-008-9148-z. * Equal contributions.

13. Samuelson AV, Klimczak RR, Thompson D, Carr CE, Ruvkun G. Indentification of C. elegans genes regulating longevity using enhanced RNAi-sensitive strains. Cold Spring Harb Symp Quant Biol 2007 72:489-97, doi: 10.1101/sqb.2007.72.068.

12. Carr CE, Newman DJ. Characterization of a lower-body exoskeleton for simulation of space-suited locomotion. Acta Astronautica 62 (2008) 308-323 (doi:10.1016/j.actaastro.2007.11.007).

11. Samuelson AV, Carr CE, and Ruvkun G. Gene activities that mediate increased lifespan of C. elegans insulin-like signaling mutants. Genes & Development 2007 Nov 15; 21(22):2976. doi: 10.1101/gad.1588907.

10. Carr CE, Newman DJ. Space Suit Bioenergetics: Cost of Transport During Walking and Running. Aviat Space Environ Med 2007; 78(12):1093-1102. doi: 10.3357/ASEM.1953.2007.

9. Carr CE, Newman DJ. Space Suit Bioenergetics: Framework and Analysis of Unsuited and Suited Activity. Aviat Space Environ Med 2007; 78:1013-1022. doi: 10.3357/ASEM.1952.2007.

8. Garrick-Bethell I and Carr CE. Working and walking on small asteroids with circumferential ropes. Acta Astronautica 2007; 61:1130-1135; doi: 10.1016/j.actaastro.2007.05.004.

7. Rader AA, Newman DJ, and Carr CE. Loping: A strategy for reduced gravity human locomotion? In 37th International Conference on Environmental Systems, Chicago, IL, July 9-12, 2007. Society of Automotive Engineers, Warrendale, PA, USA. SAE paper 2007-01-3134. doi: 10.4271/2007-01-3134

6. C.E. Carr and D.J. Newman. When is running more efficient than walking in a space suit? In 35th International Conference on Environmental Systems and 8th European Symposium on Space Environmental Control Systems, Rome, Italy, 2005. Society of Automotive Engineers, Warrendale, PA, USA (SAE 2005 Transactions Journal of Aerospace, V. 114 July 2006). SAE paper 2005-01-2970.

5. K.A. Bethke, C.E. Carr, B.M. Pitts, D.J. Newman. Bio-Suit Development: Viable Options for Mechanical Counterpressure? 34th International Conference on Environmental Systems, Colorado Springs, Colorado, July, 2004 (SAE 2004 Transactions Journal of Aerospace, V. 113 July 2005). SAE paper 2004-01-2294.

4. Carr, C.E., Newman, D.J., and Hodges, K.V., Geologic Traverse Planning for Planetary EVA, 33rd International Conference on Environmental Systems, Vancouver, Canada, 2003. Society of Automotive Engineers, Inc., Warrendale, Pennsylvania, USA. SAE paper number 2003-01-2416.

3. Hodgson, E., Sidgreaves, R., Braham, S., Hoffman, J., Carr, C., Lee, P., Marmolejo, J., Miller, J., Rosenberg, I., Schwartz, S., Requirements and Potential for Enhanced EVA Information Interfaces, 33rd International Conference on Environmental Systems, Vancouver, Canada, 2003. SAE paper 2003-01-2413.

2. Carr CE, Schwartz SJ, Rosenberg I. A Wearable Computer for Support of Astronaut Extravehicular Activity. Proceedings of the 6th International Symposium on Wearable Computers. IEEE. Seattle, October, 2002.

1. Bishop RH, Byrnes DV, Newman DJ, Carr CE, Aldrin B. Earth-Mars Transportation Opportunities: Promising Options for Interplanetary Transportation. Advances in the Astronautical Sciences, Volume 106, Proceedings of the AAS Richard H. Battin Symposium, College Station, Texas, March, 2000 (AAS 00-255).

 

Selected Talks, Abstracts, Posters (53)

55. Carr CE. The Limits of Life. Gary 66 Symposium, Boston, MA, June 11, 2018 (talk).

54. Schmidt B, McCoy K, Buffo J, Collins G, Phillips C, Pappalardo R, Doran P, Bowman J, Carr C, McEwen A, Lawrence J, Soderlund K, Nordheim TA, Sephton M, Tobie G, Glass J, Howett C, Pontefract A, Roberts J, Westlake J, Hand K, Quick L, Guidipati M, Christiansen P, Patterson GW. A Systems-Level Approach to Planetary Protection at Europa. 42nd Assembly of COSPAR (2018) (abstract PPP.2-0013-18 Paper_Id: 24558).

53. Carr CE, Ruvkun G, Zuber MT. Single Molecule Sensing and Sequencing for Life Detection Beyond Earth. Astrobiology Science Strategy for the Search for Life in the Universe, April 25-27, 2018, Washington DC (invited speaker and panelist).

52. Bryan NC, Carr CE, Zuber MT, Lebreton F, Gilmore MS. Genomic and functional characterization of desiccation tolerance in E. faecalis. 5th International Conference on Enterococci, Chamonix, France, April 15-20, 2018 (poster).

51. Carr CE, Tani J, Ruvkun G, Zuber MT. Needs and Technologies to Enable the Direct Search for Life Beyond Earth. Technologies and Infrastructures Workshop for Planetary Exploration, Horizon 2061, EPFL, April 23-25, 2018 (talk and abstract).

50. Bryan N, Bhattaru SA, Saboda K, Ruvkun G, Zuber MT, Carr CE. DNA Sequencing During Simulated Mars, Europa, and Zero Gravity. MIT Media Lab Zero Gravity Flight Research Symposium. Jan 23, 2018 & MIT Media Lab Beyond the Cradle 2018, March 14, 2018 (poster).

49. Carr CE. Opportunities and Challenges for Life Detection via 'Omics' Approaches. ELSI/EON International Workshop on Life Detection, Earth Life Science Institute, Tokyo Institute of Technology, Japan. October 2017 (planned; invited speaker).

48. Carr CE. On the Search for Informational Polymers Beyond Earth. Earth Life Science Institute, Tokyo Institute of Technology, Japan. August 1, 2017 (invited seminar).

47. Carr CE. The Future of Life Beyond Earth. Panel: The Coming (R)EVOLUTION: Tech’s Impact on Life as We Know It. United States – Japan Leadership Program, Kyoto, Japan, July 28, 2017 (invited talk).

46. Carr CE. Are you In or Out? From Evolution to an Automated Future. Panel: Mind the Gap: Coping With an Era of Growing Inequality. United States – Japan Leadership Program, Tokyo, Japan, July 25, 2017 (invited talk and panel chair).

45. Carr CE. On the Search for Informational Polymers Beyond Earth. Osaka University, Japan. July 20, 2017 (invited seminar).

44. Carr CE and Newman DJ. Exoskeleton Energetics: Implications for Planetary Extravehicular Activity. NASA Open EVA Human Research Forum, May 17, 2017 (online telecom; invited).

43. Carr CE. Towards In Situ Sequencing for Life Detection. Future In-Space Operations Telecon, University of Texas, May 3, 2017 (http://fiso.spiritastro.net/telecon.htm; invited talk). Audio & Slides

42. Carr CE, A. Mojarro, J. Hachey, A. Pontefract, R. Doebler, M. Brown, G. Ruvkun, and M. T. Zuber. Progress and Challenges for Life Detection via Nucleic Acid Sequencing. Astrobiology Science Conference, Mesa, Arizona, April 24–28, 2017. Abstract #3395 https://goo.gl/Tshurk

41. J. Hachey, A. Pontefract, M. T. Zuber, G. Ruvkun, C. E. Carr. Sequencing Nothing: Exploring Failure Modes of Nanopore Sensing and Implications for Life Detection. Astrobiology Science Conference, Mesa, Arizona, April 24–28, 2017. Abstract # 3454 https://goo.gl/AnEcJK

40. J. Creamean, C. Carr, B. Christner, K. Pratt, R. Sheesley, W. Simpson, N. Spada, J. Stutz. Understanding the Impacts of Aerosols and Trace Gases in the Central Arctic during MOSAiC. MOSAiC workshop (4 – 5 April); ASSW 2017, Prague, Czech Republic (abstract + poster).

39. A. Mojarro, J. Hachey, R. Bailey, M. Brown, R. Doebler, G. Ruvkun, M. T. Zuber, C. E. Carr. Nucleic Acid Extraction and Sequencing from Low-Biomass Synthetic Mars Analog Soils. Lunar & Planetary Sci XLVIII, The Woodlands, Texas, March 21-25, 2017. Abstract # 1585 (poster) https://goo.gl/6xeAJJ

38. A. Pontefract, J. Hachey, A. Mojarro, V. K. Walker, H. Rowedder, T. F. Zhu, C. Lui, M. T. Zuber, G. Ruvkun, C. E. Carr. Understanding Habitability and Biosignature Preservation in a Hypersaline Mars Analog Environment: Lessons from Spotted Lake. Lunar & Planetary Sci XLVIII, The Woodlands, Texzas, March 21-25, 2017. Abstract # 1124 https://goo.gl/YBBRg6

37. Tani J, Ruvkun G, Zuber MT, Carr CE. On Neuromorphic Architectures for Efficient, Robust, and Adaptable Autonomy in Life Detection and Other Deep Space Missions. Planetary Science Vision 2050 Workshop, Washington, DC - Feb 27-Mar 1, 2017. Abstract # 8080, https://www.hou.usra.edu/meetings/V2050/pdf/8080.pdf, e-poster: https://goo.gl/1eWQsR

36. J. Hachey, A. Mojarro, J. Tani, A. Smith, A. Pontefract, S. A. Bhattaru, K. Saboda, G. Ruvkun, M. T. Zuber, and C. E. Carr. Single Molecule Sequencing for Life Detection Beyond Earth. Nanopore Community Meeting, New York, NY, December 1-2, 2016 (poster + talk), Video: https://nanoporetech.com/events/ncm16-lightning#195038663

35. Carr CE. On the Search for Informational Polymers Beyond Earth. Harvard Origins Initiative, Cambridge, MA, December 1, 2016 (invited chalk talk).

34. A. Mojarro, J. Hachey, J. Tani, A. Smith, S. A. Bhattaru, A. Pontefract, R. Doebler, M. Brown, G. Ruvkun, M. T. Zuber, C. E. Carr. SETG: Nucleic Acid Extraction and Sequencing for In Situ Life Detection on Mars. 3rd International Workshop on Instrumentation for Planetary Missions. Pasadena, CA, October 24-27, 2016. Abstract #4095. http://www.hou.usra.edu/meetings/ipm2016/pdf/4095.pdf

33. Carr CE, Hachey J, Smith A, Mojarro A, Pontefract A, Tani J, Zuber MT, Ruvkun G. Single molecule sequencing and the search for life beyond Earth. Cold Spring Harbor Asia, Microbiology and the Environment, Suzhou, China (September 26-30, 2016; invited speaker; session co-chair).

32. Mojarro, A., Ruvkun, G., Zuber, M. T., Carr, C. E. The Search for Extra-Terrestrial Genomes. Biosignatures and the Search for Life on Mars, Iceland, July 1-14, 2016 (poster).

31. Mojarro, A., Ruvkun, G., Zuber, M. T., Carr, C. E. The Search for Extra-Terrestrial Genomes: Nucleic Acid Extraction from Mars Analog Soils. 2016 Northeastern Geobiology Symposium, Poster.

30. Pontefract, A., Mojarro, A., Smith, A., Walker, V., Zuber, M., Ruvkun, G. and Carr, C.E. 2016. The Search for Unambiguous Biosignatures: DNA Extraction and Sequencing in Mars Analogue Environments. 2016 Northeastern Geobiology Symposium, Poster.

29. Harrison TN, Pontefract AJ, Osinski GR, Tornabene LL, Battler M, Carr CE, Conway SJ, Soare RJ. Hydrogeological Constraints on Gully Formation and the Effects on Microbiological Colonization. Lunar & Planetary Sci XLVII, The Woodlands, Texas, March 21-25, 2016. Abstract # 2247, https://www.hou.usra.edu/meetings/lpsc2016/pdf/2247.pdf

28. Mojarro A, Ruvkun G, Zuber MT, Carr CE. Methods for Extracting Nucleic Acids from Mars Analog Regolith. Lunar & Planetary Sci XLVII, The Woodlands, Texas, March 21-25, 2016. Abstract # 1643, https://www.hou.usra.edu/meetings/lpsc2016/pdf/1643.pdf

27. Mojarro, G. Ruvkun, M. T. Zuber, C. E. Carr. (2015) Human Exploration of Mars at Valles Marineris: The Past, Present, and Future of Life on Mars. First Landing Site/Exploration Zone Workshop for Human Missions to the Surface of Mars, Houston, TX, Oct 27-30. Abstract #1036, https://www.hou.usra.edu/meetings/explorationzone2015/pdf/1036.pdf

26. Webber MW, Mojarro A, Ruvkun G, and Carr CE. Growth and Sequencing of Acidophiles from Volcan Copahue, Argentina. Astrobiology Graduate Conference. Madison, WI. 21 July 2015

25. Carr CE. How to make life and influence planets: Life Beyond Earth. MIT Museum Lecture Series, October 28, 2014 (invited talk).

24. Carr CE. The Search for Extra-Terrestrial Genomes. LSU Dept. of Biology, Sep 29, 2014 (invited talk).

23. Carr CE. Is it time to search for life on Mars? American University, July 31, 2014 (invited panel member).

22. Carr CE. The Search for Extra-Terrestrial Genomes in Space Radiation – From Simulation to Survival.  13th Int’l Workshop on Radiation Damage to DNA, Cambridge, MA, June 14-18, 2014 (invited talk).

21. Carr CE. What does life on Mars have to do with public health? Pennsylvania Department of Health, Epidemiology Journal Club, Harrisburg, Pennsylvania, January 14, 2014 (invited talk).

20. Carr CE, Ruvkun G, Zuber MT. Life Detection with the Enceladus Orbiting Sequencer (EOS). Aerospace Conference, 2012 IEEE (Abstract Submitted 31 July 2012).

19. Wang MC, Doebbler HD, Carr CE, Sowa JN, Ruvkun G. A comprehensive functional genomic screen for genes that regulate Caenorhabditis elegans reproductive senescence. Molecular Genetics of Aging, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, Oct 9-13, 2012 (abstract, talk).

18. Carr CE, Ruvkun G, Zuber MT. Beyond RNA and DNA: In-situ Sequencing of Informational Polymers. International Workshop on Instrumentation for Planetary Missions (2012), NASA Goddard Space Flight Center, Greenbelt, Maryland, Oct 10-12, 2012 (extended abstract 1136).

17. Carr CE, Ruvkun G., and Zuber M.T. In-situ Sequencing for Life Detection, Human Health, and Planetary Protection. Concepts and Approaches for Mars Exploration, Houston, Texas, Jun 12-14, 2012 #4210 (abstract only; http://www.lpi.usra.edu/meetings/marsconcepts2012/pdf/4210.pdf).

16. Kobrick R, Carr CE, Meyen F, Domingues AR, and Newman DJ. Using inertial measurement units for space vehicle safety, comfort, design, and performance optimization. Next Generation Suborbital Researchers Conference Feb 27-29, 2012, Palo Alto, CA (extended abstract).

15. Carr CE, Lui CS, Rowedder H, Zuber MT, Ruvkun G. Nucleic-Acid Sequencing for Life Detection and Characterization. Conference on Life Detection in Extraterrestrial Samples, Feb  2012.

14. Carr CE. The Search for Extra-Terrestrial Genomes. Worcester Polytechnic Institute, Biomedical Engineering Seminar, 18 Jan 2012 (invited).

13. Carr CE. The Search for Extra-Terrestrial Genomes. MIT Lincoln Lab, Office of the Director Seminar Series, 23 Sep 2011 (invited talk).

12. Carr CE, Rowedder H, Vafadari C, Lui C, Cascio E, Zuber MT, and Ruvkun G. Radiation sensitivity of biological reagents for life detection on Mars. The International Conference: Exploring Mars Habitability, June 13-15, 2011, Lisbon, Portugal (abstract/poster).

11. Lui C, Carr CE, Zhu T, Johnson SS, McManus K, Zuber MT, and Ruvkun G. Sampling and sequencing Volcán Copahue, an acidic, sulfur-rich terrestrial analog of Mars. The International Conference: Exploring Mars Habitability, June 13-15 2011, Lisbon, Portugal (abstract/talk).

10. Zhu T, Carr C, Lui C, Zuber M, Ruvkun G. Self-replicating Cell-like Membrane Systems: Could They Exist on Mars? The International Conference: Exploring Mars Habitability, June 13-15 2011, Lisbon, Portugal (abstract).

9. Carr CE. The Search for Extra-Terrestrial Genomes: A life detection instrument with biological components. NASA workshop on synthetic biology, Oct 30-31 2010. (invited talk/abstract/poster).

8. Carr CE. Adventures in Sequence Space. Pennsylvania Department of Health, Epidemiology Journal Club, Harrisburg, Pennsylvania, March 9, 2010 (invited talk). MGH Department of Molecular Biology, Department-Wide Seminar, March 26, 2010 (invited talk).

7. Carr CE. Space Exploration: Mediating the Void. MIT Visual Arts Program Evening Lecture Series, October 1, 2007 (invited).

6. Carr CE, Zuber MT, Ruvkun G. Did Earth-Mars meteoritic exchange spread microbial life? DNA-based life detection for Mars, with human spaceflight applications. American Society for Gravitational and Space Biology, Annual Meeting, November 2006 20(1) (talk/abstract).

5. Vahora N, Carr CE, Zuber MT, Ruvkun G. DNA-Based Life Detection on Earth and Mars: Polymerase Chain Reaction Optimization Using Short Ribosomal Primers. American Society for Gravitational and Space Biology, Annual Meeting, November 2006 20(1) (abstract).

4. Treviño L and Carr CE. A first-order design requirement to prevent edema in mechanical counter-pressure space suit garments. Aviat Space Environ Med 76(3):220, 2005 (abstract).

3. Brown EL, Carr CE, and Wooster P. The Mars Gravity Biosatellite: A New Platform for Partial Gravity Research. J. Gravitational Physiology 10(1):P9-10, July 2003 (extended abstract).

2. Carr CE, Woodbury D, Hutchison WE, Fuller E, Akciz SO, Niemi NA, Nyugen HQ, Sheehan DD, Hodges KV, and Burchfiel BC. A Wireless Digital Compass for Field Geology. Geological Society of America, Abstracts with Programs Vol. 34, No. 6, September 2002 (poster).

1. Carr CE, and Newman DJ. Supporting Martian Field Geology. Geological Society of America, Annual Meeting, Boston, Massachusetts, October 2001 (poster).

 

Other Publications (15)

15. Carr CE. Paleomicrobiology of Humans. Emerging Infectious Diseases. 2018;24(3):609. doi:10.3201/eid2403.171908 (book review).

14. Giri C, Jia T, Cleaves HJ, Usui T, Bodas D, Carr C, Chen H, Fujii Y, Furukawa Y, Genda H, Gillams RJ, Hamano K, Kameda S, Krishnamurthy R, Meinert C, Meringer M, Paknikar K, Rajamani S, Shivaji S, Steele A, Taniguchi M, Yabuta H, Yamagishi A. Life Detection Technologies for the Next Two Decades. National Academy of Sciences, Engineering, and Medicine, Space Studies Board, Astrobiology Science Strategy for the Search for Life in the Universe. White Paper. Submitted 1/7/2018.

13. Carr CE, Bryan NC, Saboda K, Bhattaru SA, Ruvkun G, Zuber MT. Acceleration Profiles and Processing Methods for Parabolic Flight. arXiv:1712.05737; code: https://github.com/CarrCE/zerog; data: https://osf.io/nk2w4/

12. Mojarro A, Hachey J, Ruvkun G, Zuber MT, Carr CE. CarrierSeq: a sequence analysis workflow for low-input nanopore sequencing. bioRxiv https://doi.org/10.1101/175281; code: https://github.com/amojarro/carrierseq; data: https://doi.org/10.6084/m9.figshare.5471824.v1 

11. Kobrick R, Carr CE, Meyen F, Domingues AR, Newman DJ, and Jacobs SE. Using inertial measurement units for measuring spacesuit mobility and work envelope capability for intravehicular and extravehicular activities. 63rd International Aeronautical Congress, Oct 1-5, 2012, Naples, Italy (paper IAC-12-A1.6.6). Supporting information (space suit motion tracking): http://www.youtube.com/watch?v=xtPeqcMzf_4

10. Karouia F, Carr C, Cai Y, Chen Y, Grenon M, Larios-Sanz M, Jones J, Santos O. Synthetic Biology and Human Health: Potential Applications for Spaceflight. NASA Technical Reports Server, April 2011, http://ntrs.nasa.gov/search.jsp?R=20110014422.

9. Ruvkun G, Samuelson AV, Carr CE, Curran SP, Shore DE. Signaling Pathways that Regulate C. elegans Life Span. In Clemmons DR, Robinson I, Christen Y (eds.). IGFs: Local Repair and Survival Factors Throughout Life Span, Research and Perspectives in Endocrine Interactions, doi:10.1007/978-3-642-04302-4_6, Springer-Verlag Berlin Heidelberg 2010.

8. Carr CE. Classics in Space Medicine. Prolonged Exposure in the Navy Full Pressure Suit at "Space Equivalent" Altitudes. Aviat Space Environ Med 2010 Feb;82(2):151-152.

7. Carr CE. Classics in Space Medicine: Motion Performance of Pressure-suited Subjects under Zero and Lunar Gravity Conditions. Aviat Space Environ Med 2010 Apr;81(4):440-1.

6. Carr CE. Entries for “MIR space station” and “Shuttle-MIR Program” in Johnson SB (ed). Space Exploration and Humanity: A Historical Encyclopedia. Santa Barbara, California: ABC-CLIO, August 2010.

5. Carr CE. “Assigning electoral votes fairly in close races.” OpEd. The Providence Journal, November 2, 2004, page B4 (Metro edition).

4. Newman DJ, Bethke K, Carr C, Hoffman J, and Trotti G. Astronaut Biosuit System to Enable Planetary Exploration. International Astronautical Congress, Vancouver, Canada, October 4-8, 2004.

3. Carr CE. “After X-Prize, Diamandis sets sights on next steps”, HST Connector, 2005/Winter

2. Carr CE. “Bringing space to the public; Sending the public to space” (Alumnus Profile of Peter H. Diamandis), HST Connector, 2004/Fall

1. Carr CE, Schwartz SJ, Newman DJ. Preliminary Considerations for Wearable Computing in Support of Astronaut Extravehicular Activity. MIT Media Lab Technical Report # 551 (2001). http://hd.media.mit.edu/tech-reports/TR-551.pdf

 

Other Abstracts (citable only as personal communications, 7)

7. Pino E, Carr C, Soukas A. A Genome-Wide RNAi Screen of Caenorhabditis elegans Identifies Translational Machinery Genes Involved in Fat Regulation. International C. elegans Meeting, 2013.

6. Samuel B, Durfee T, Rowedder H, Carr C, Melo J, Glasner J, Sykes S, Young S, Russ C, Plunkett G, Nusbaum C, Ruvkun G. Wormfood Genomics: E. Coli determinants of C. elegans’ fitness. International C. elegans Meeting, 2011.

5. Samuelson A, Ruvkun G, Carr C. Insulin signaling pathway genes facilitating the maintenance of thermotolerance and protein homeostasis. International C. elegans Meeting, 2009.

4. Soukas A, Kane E, Carr C, Samuel B, Melo J, Ruvkun G.  Rictor/TOR complex 2 regulates fat metabolism, feeding, growth, and lifespan in C. elegans. International C. elegans Meeting, 2009.

3. Samuelson A, Irazoqui J, Powell J, Carr C, Ausubel F, Ruvkun G. Characterization of gene inactivations identified in a functional genomic screen for accelerated aging based on changes in stress resistance. International C. elegans Meeting, 2007.

2. Samuelson A, Carr C, Ruvkun G. Uncoupling daf-2 lifespan extension: pathway specificity, demographic, and movement rate analysis of gene inactivations identified in a functional genomic screen for accelerated aging. International C. elegans Meeting, 2007.

1. Samuelson A, Carr C, Ruvkun G. Functional genomic analysis for gene inactivations that accelerate aging reveals a role for endocytosis-associated mediators. International C. elegans Meeting, 2007.